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7 Best Natural Antidepressants: A Complete Guide

speciality medications

July 12, 2022
Best Natural Antidepressants

Over 17 million American adults suffer from depression.

If you’re one of them, you know how life-changing the proper medication can be. Depression, along with related disorders such as anxiety and OCD, is often treated with either medication, lifestyle interventions, or psychotherapy.

As each of these interventions tend to cost quite a bit of money, there’s a rising interest in another type of anti-depression treatment:

Supplements – or natural antidepressants.

Some research out there may indicate that taking some specific herbs, minerals, or vitamins can help some people reduce some depressive symptoms.

However, these natural antidepressants are often not approved by government health authorities, and many don’t require prescriptions at all.

As a result, it can be hard to know which natural antidepressants are effective, safe, and suitable for you.

Even if a specific natural antidepressant seems like it’s working wonders for your friend or strangers on the Internet, it’s vital to talk with your doctor before adding any supplements to your ongoing care plan.

Here, we’ll go over some basic information and research about several popular natural antidepressants, including ones you can buy easily online, so you can make the best choice possible for you.

7 Best Natural Antidepressants

Omega-3 Fatty Acids Supplements: Benefits and Costs

Although a fatty acid may not sound like a particularly healthy thing, Omega-3’s are essential for our daily health and happiness.

They’re also not something that our bodies make on their own. We need to get them from our diet.

What’s more:

Recent studies show that omega-3 supplements may be natural antidepressants with some efficacy.

In 2020, a group of researchers working out of Beijing, China, took a look at the depressive symptoms experienced by over 600 pregnant and postpartum women. The researchers noticed that women taking supplements containing EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) experienced reduced depressive symptoms.

These substances – EPA and DHA – are omega-3 fatty acids. They’re present in high amounts in seafood. However, to get the amounts necessary to experience any change in mental health, you would likely have to eat large amounts of seafood every day – making a supplement a convenient alternative.

This 2020 review isn’t alone.

For example, a meta-analysis conducted in 2019 looked at 26 different studies examining the relationship between omega-3 supplementation and depressive symptoms. This meta-analysis found that a dose of omega-3 that contained 60% or more EPA was the most effective at reducing symptoms.

While this data may seem promising, it’s important to remember that natural antidepressants such as omega-3s may work differently for different people.

Even though omega-3 supplements may be freely available over the counter, you should speak with your doctor or a pharmacist about this supplement before taking it.

If after consulting your doctor you do feel that omega-3 supplementation would be beneficial, you can buy it through Here, you can find a pack of 30 omega-3 soft gels – about a one-month supply – for around $20.00.

Best Natural Antidepressants

Vitamin D Supplements: Benefits and Costs

You may be familiar with vitamin D as the “sun” vitamin – or the one that your body starts to make after exposure to rays from the sun.

While it’s true that a safe amount of sun exposure can help your body produce more vitamin D, some people (especially those with sensitive skin or in northern climates) may require an alternative option to ensure they’re getting enough.

There seems to be a link between a deficiency in vitamin D and depressive symptoms. One study found that, of the people tested, those with the lowest vitamin D levels had the more severe symptoms of depression.

On the flip side, we are learning that Vitamin D supplements, as natural antidepressants, may be able to help some people with depression feel better in several ways.

For example, one 2020 study suggests that Vitamin D may:

  • Reduce systemic inflammation (including inflammation in a patient’s brain)
  • Help with regulating a patient’s moods, and
  • Even assist with protecting a patient against neurocognitive dysfunction.

A review published in 2019 covered a series of studies demonstrating that these factors may have measurable, visible benefits for sufferers of depression. Of the patients enrolled in these studies who took Vitamin D supplements, many experienced reduced symptoms.

If you’re interested in trying Vitamin D to see whether it works for you and your lifestyle, you can pick it up through We sell vitamin D starting at around $17.00 for 90 tablets, or an approximate three-month supply.

B-Complex Supplements: Benefits and Costs

B vitamins, much like fatty acids and Vitamin D, are crucial for optimal health and happiness.

As the name ‘B-complex’ may suggest, this supplement usually includes several B vitamins. These include:

  • Folate
  • B12
  • B6
  • Inositol
  • Biotin
  • Niacin
  • Thiamine

These B vitamins work together to produce and regulate many different neurotransmitters. Some of these neurotransmitters, such as serotonin and dopamine, are famously responsible for our happiness and mood regulation.

When researchers tested the efficacy of B complex supplementation as a type of natural antidepressant, they found that people at a high risk of depression often experienced reduced symptoms after consistent B complex use.

If your doctor has recommended a specific type of antidepressant medication, there’s also evidence that taking a B vitamin alongside your prescription meds could be beneficial.

Want to buy a B-complex vitamin online to see if it works well for you? Here, you can buy a Vitamin B supplement starting at around $20.00 for 90 tablets, or a three-month supply.

Best Natural Antidepressants

Magnesium Supplements: Benefits and Costs

Magnesium is often dubbed a ‘calming’ or ‘anti-anxiety’ mineral.

This may indicate that using magnesium supplements as natural antidepressants can benefit people suffering from anxiety and depression.

So far, researchers have seen this correlation play out when studying magnesium’s effect on patients with major depressive disorder. In fact, one 2008 study reported that taking magnesium may have a similar impact on depressive symptoms as prescription antidepressants in some particular circumstances.

Working within your doctor’s plan for your specific mental health success will always be the best plan, as you and your symptoms are unique.

Magnesium may even provide relief and calmness for people who aren’t necessarily suffering from major depression. For example, a 2017 scientific paper reported that taking magnesium daily for six weeks improved depressive symptoms for over 120 people with mild or moderate depression.

American patients who seek the ease and privacy of online purchasing can buy their magnesium through at a low cost. We offer magnesium supplements starting at around $10.00 for 60 capsules (or about a two-month supply).

Tryptophan Supplements: Benefits and Costs

If Tryptophan sounds familiar, that may be because it’s an amino acid found in high levels in turkey. Those who live in the United States may associate tryptophan with the pleasantly relaxed, sleepy feeling after enjoying a traditional Thanksgiving dinner.

Interestingly, the medical community is finding that leveraging that same sense of post-holiday calm can benefit people struggling with their mental health.

Taking Tryptan or generic tryptophan can help people achieve a range of specific goals, including:

  • Balancing their hormones naturally
  • Regulating their moods more easily
  • Making more serotonin
  • Enjoying less anxiety
  • Sleeping better
  • Treating migraines without other medication

There’s some research out there that suggests tryptophan may work as a vasoconstrictor. So if you’re suffering a cluster headache or a migraine attack, taking tryptophan may manage blood flow strategically to provide timely relief.

Unlike many natural antidepressants on this list, Tryptan and generic tryptophan are prescription medications.

At, you can buy tryptophan online at a low price of around $84.00 for 100 tablets (just over a three-month supply) with a prescription from your doctor.

NAC (N-Acetyl Cysteine) Supplements: Benefits and Costs

NAC, or N-Acetyl Cysteine, is a specific substance that your body can process into two crucial amino acids: Glutathione and L-cysteine.

Each amino acid is essential for your best mental health, but glutathione, in particular, is vital for your body’s optimal function. Glutathione is one of your body’s go-to antioxidants. In addition, glutathione is beneficial for reducing inflammation and protecting your cells from oxidative damage.

Because glutathione is vital for these processes, supplementing with NAC to keep our glutathione levels high is often correlated with many beneficial outcomes.

For example, supplementation with NAC has been demonstrated to:

One 2016 meta-analysis even showed that, compared to people with depression who took a placebo, NAC was able to help people with depression function better and experience reduced depressive symptoms.

Best of all, NAC doesn’t have to cost much: In America, NAC is even widely available over the counter for $10.00 – $30.00 for 3-4 month’s treatment. Be sure to check with your health provider before starting this affordable and accessible treatment.

Best Natural Antidepressants

SAM-e (S-adenosylmethionine) Supplements: Benefits and Costs

SAM-e (or S-adenosylmethionine) is a naturally occurring substance that may be able to treat depression in some cases when used as a daily supplement.

One 2011 analysis showed that supplementation with SAM-e was correlated with improving depressive symptoms. (Critics of these studies quickly point out that these trials had some design flaws that brought their results into question.)

If you’re interested in the benefits SAM-e may be able to offer, it’s worth doing your research. Your healthcare professional will also be able to help you make the best decision for your specific diagnosis and symptoms.

However, you should be aware that SAM-e as a natural antidepressant may not be for everyone.

Some professionals advise against SAM-e supplementation for people with HIV, Parkinson’s, and bipolar disorder, as SAM-e may reduce the efficacy of medications for these diseases or even accentuate some of their related symptoms.

You can purchase SAM-e here – it costs approximately $45.00 for 30 pills.

Alternatives to Natural Antidepressants

If you don’t find natural antidepressants or your doctor suggests you need mental health medications, that’s okay! carries antidepressants that are not strictly considered ‘natural,’ but are known to be safe and effective.

These include:

  • Wellbutrin XL (bupropion extended-release), a drug that can help patients balance their brain’s neurotransmitters and pursue better mental health. At, we sell 90 tablets of brand-name Wellbutrin for about $126.00, or $1.40 per dose.
  • Prozac (fluoxetine), an SSRI, can help patients with panic disorder, OCD, and bipolar disorder reduce their depressive and anxious symptoms. While Prozac is available in the United States for about $18.00 per dose, you'll pay a lot less if you purchase Prozac through Here, we sell brand-name Prozac for about $3.00 per dose – in packs of 100, or a three-month supply, for around $300.00.
  • Zoloft (sertraline) is another SSRI, much like Prozac. Zoloft is often prescribed to treat premenstrual dysphoric disorder, panic and anxiety, OCD, and major depressive disorder. If you buy a three-month supply of Zoloft through, you’ll pay approximately $130.00, or about $1.50 per dose.

Ultimately, while SAM-e, magnesium, tryptophan, and NAC, omega-3s, vitamin D and B-complex may help patients combat their depressive symptoms, you still need to exercise caution if you’re using these supplements.

While some of these are more natural options, they may still have a real effect on your body. They may also interact with any prescription medications you may be taking.

Before adding these natural supplements to your diet, make sure you speak with a trusted healthcare professional.

Order Natural Antidepressants Through a Safe Online Canadian Pharmacy and International Medications Site

If you or a loved one is struggling with frustrating mental health symptoms, the last thing you need is a trip to a brick-and-mortar pharmacy. Standing in line, paying sky-high fees for your supplements and medications, and even having to interact with other people may be more than you need right now.

That’s why we make sure that ordering medications through our safe and trusted Canadian online pharmacy and international drugstore is private, painless, and an overall piece of cake.

By taking advantage of online-only perks (such as secure payment processes and the ability to price-check medications with just a few clicks) you can order the supplements and medications you need from your own home.

In addition, you can be confident you’re getting a great product because we adhere to strict safety standards (such as the Canadian International Pharmacy Association (CIPA) and the International Pharmacy Association of British Columbia (IPABC)).

And, of course, you’ll end your medication-purchasing experience by having everything delivered directly to your front door.

All of this saves time and money so you can rest, relax, and invest in your health and happiness in other ways!

If you’re ready to purchase natural antidepressants or other treatment options, give our team a call. We have a responsive and friendly customer service desk which is open seven days a week. They’ll be more than happy to help you answer any questions you may have, connect you with a pharmacist, or help you order over the phone.

Give us a call at 1-866-539-5330, or contact us online, and we’ll respond promptly. We’re ready to help you invest in your mental health.

The information provided on the website is intended to facilitate awareness about healthcare products and medical conditions generally but it is not a substitute for professional medical attention or advice. You should always speak with a qualified healthcare practitioner before taking any prescription or non-prescription drug.
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