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11 Popular Medications for Women in Menopause

women’s health

September 7, 2021
Menopause Medication

If you’re sick of hot flashes, night sweats, and vaginal dryness, you’ve hopefully talked to your doctor about finding some relief. You may have discussed options such as the Estring or the Vivelle Dot, but perhaps found they were too expensive or difficult to locate in the United States.

Whether it’s sweaty, sleepless nights, painful intercourse, or the stigma associated with menopause that’s frustrating you, the price of medication should not be a hindrance. While these symptoms may not be life-threatening, they may be degrading your quality of life.

Fortunately, you can take control of your menopause symptoms. While menopause is a natural transition that every woman goes through eventually, you shouldn’t have to suffer through it.

But you also shouldn’t be forced to pay exorbitantly high prices to alleviate your menopause symptoms. At, we know that menopause medications don’t need to be expensive.

Here, you’ll find the most popular medications for women going through menopause available at, and just how much you can save by shopping through an online Canadian pharmacy. (Hint: You can save up to 90%.)

Hormone Replacement Creams and Gels

Premarin Vaginal Cream Cost

Premarin Vaginal Cream (conjugated estrogens) is a cream that provides relief for vaginal dryness.

During menopause, the amount of estrogen the body makes decreases. There are several types of the hormone estrogen, including estrone, estradiol, and estriol.

Having low levels of these hormones can impact vaginal tissue health, leading to vaginal dryness and itchiness. In some cases, women even experience severe pain that can make it difficult (if not impossible) to enjoy sex.

Premarin is applied directly into the vaginal canal and is absorbed through the skin. One medication delivering all three types of estrogen is convenient, which is one of the reasons Premarin is so popular.

Premarin makes it easier to support your vaginal tissue so you can live your life the way you’re accustomed to. Depending on your recommended dose and treatment schedule, one 30-gram tube of Premarin may last you anywhere from one to six months. In the United States, you can purchase Premarin for about $462.00, or $15.40 per gram.

At, you can find the same 30-gram tube of Premarin for about $60.00, or approximately $2.02 per gram. That’s a savings of about 87%.

Divigel Cost and Convenience

Divigel (estradiol topical gel) is a topical, odorless solution that is used to treat some of the symptoms associated with menopause. While there are a few options for hormone regulation in this area, Divigel was designed for simplicity with three easy steps.

  • Step 1: Rip open the packet.
  • Step 2: Rub the pre-measured gel across your upper thigh.
  • Step 3: Repeat daily.

Divigel can relieve hot flashes and other menopause symptoms. But it does so without the need to measure out doses or tote around bulky containers while traveling.

Divigel is a concentrated solution, which means the dose can be smaller. Divigel is odorless, will dry quickly, and leave no residue. It’s absorbed through your skin, which allows it to hit your bloodstream faster than an oral medication would.

In the United States, you can buy a 30-day supply of Divigel in a range of concentrations for about $195.00.

At, you can purchase a 30-day supply of Divigel for $71.00 — a savings of about 64%.

Alternatively, you can save more with a 12-week supply for about $165.00 and free shipping. Doing so makes the cost per dose with as low as $1.96.

Estrogel Cost (Brand Name)

Estrogel (estradiol 17Beta) provides a low-dose, one-pump, once-a-day solution to manage both hot flashes and moderate vaginal irritation.

Managing menopause symptoms can feel less-than-discreet — after all, hot flashes can happen at any time. With Estrogel, you apply a straightforward dose (one pump into the palm of your hand) to your arm or upper thigh. Estrogel will dry odorless in 2-5 minutes.

It may be difficult to find brand-name Estrogel in America, as there is a generic equivalent widely available. A 40-day supply of the generic medication costs about $286.00, or $7.15 per dose.

If you require brand name Estrogel, you’re in the right place. At, a 64-day supply of Estrogel is about $42.00, or $0.65 per dose — a savings of about 91%.

Menopause Medication

Estrogen Patches

Climara Cost

Climara (patch estradiol) is an estrogen derivative, delivered through a patch you place on your skin. The patch should be placed on your lower abdomen and will release estradiol continuously for one week.

This boost of estrogen can help support the lining of your vaginal wall and increase natural lubrication. Decreased lubrication combined with thinning tissue is often the primary source of painful intercourse during and post-menopause.

Climara can also help you maintain your bone density. Estrogen replacement with the Climara patch can protect the bone cells responsible for forming new bone growth over time.

In the U.S., a generic equivalent of Climara is widely available. You can find a 1-month supply of the generic medication for $65.00 to $80.00, depending on the specific dose your doctor recommends.

Need brand-name Climara? At, you’ll find prices as low as $38.00 for a 1-month supply, or a convenient 6-month supply for as low as $193.00, depending on your dose.

Alternatively, you can purchase the generic medication on, as well. You’ll find a 2-month supply costs about $48.00 — a savings of about 63%.

CombiPatch Cost and Convenience

The CombiPatch, or Estalis Patch, (estradiol/norethindrone acetate), works by providing a combination of two hormones: estradiol (an estrogen) and norethindrone (a progestin).

Some doctors may recommend taking estrogen and progestin together to protect your uterus from any side effects of hormone replacement therapy. If your doctor recommends this for you, the aptly-named CombiPatch simplifies your care regimen by combining both hormones in one transdermal patch.

The CombiPatch targets multiple low-estrogen symptoms including vaginal dryness and hot flashes. It requires twice-weekly replacement and adheres to skin strongly enough that you can shower, bathe, or even swim while wearing it.

In the U.S., you can find a 4-week supply for between $268.00 and $280.00, depending on the dose you need.

Alternatively, at, you can buy the same 4-week supply of the CombiPatch for about $60.00 (78% savings), or a 12-week supply for about $135.00 (83% savings).

Vivelle Dot Cost

The Vivelle Dot, or Estradot, (estradiol-17b), supplies estradiol to your bloodstream transdermally, much like Climara. However, the Vivelle Dot is available in a wider range of doses and can be replaced either once per week or twice.

The wider range of doses and potentially longer wearing period can offer you more control over your care regimen. For example, if you and your doctor have discussed the need for varied doses or a specifically-timed treatment schedule, the Vivelle Dot offers the options and flexibility you need.

The Vivelle Dot provides relief for some menopause symptoms, including vaginal dryness and even irritation associated with urinating.

While the Vivelle Dot is available in the United States, there is a generic widely available for a lower price. The generic costs about $90.00 for a 4-week supply.

At, you can purchase the same 4-week supply of the Vivelle Dot for about $39.00 (57% savings). You can also purchase a three-month supply for as little as $78.00 (71% savings), depending on the dose you require.

Hormone Replacement Tablets and Capsules

Vagifem Tablet Cost

Vagifem (estradiol) supplies estradiol directly to vaginal tissue — in tablet form. After insertion of Vagifem, the tablet slowly dissolves and releases estradiol locally, where it’s needed most.

This form of localized estrogen therapy may offer more timely relief from dryness or itchiness than a transdermal patch or oral estrogen. Additionally, localized treatment options like Vagifem may be better for people with a family history of certain cancers because less enters the bloodstream.

Vagifem comes with an applicator (similar to that of a tampon) to aid insertion. It may be helpful to insert Vagifem just before you go to bed, as laying down may help the medication absorb more effectively. However, you can take Vagifem at any time — it’s more important to take it around the same time each day.

In the United States, 18 tablets, or a typical starter-month supply of Vagifem, costs $450.00, or $25.00 per dose.

You can purchase the same one-month supply of Vagifem at for just $72.00, or approximately $4.00 per dose — a savings of about 84%.

Once you’ve started your initial month and you’re taking maintenance medication, most patients are told to use Vagifem twice per week. This would amount to about eight pills per month.

Menopause Medication

Prometrium Cost

Prometrium (progesterone) is a form of bioidentical hormone therapy. This means Prometrium provides a hormone chemically identical to the progesterone your body naturally produces.

Often, doctors prescribe Prometrium for women who are also taking an estrogen hormone replacement medication. The two hormones together can provide increased benefits, including improved sleep quality, lowered anxiety, and uterine safety.

Prometrium is a capsule that women can be formulated to be taken orally or vaginally. As with Vagifem, it may make sense to take vaginal capsules as the last step in your evening routine.

Depending on the dose your doctor prescribes, Prometrium in the United States can cost anywhere from $378.00 to $663.00 for 30 capsules.

Alternatively, 30 capsules of Prometrium costs as little as $65.00 (a savings of at least 83%, depending on the dose) at also has the generic equivalent, about $25.00 for 30 capsules.

Premarin Tablet Cost

Premarin (conjugated estrogens - CES) may sound familiar, as we discussed Premarin Vaginal Cream above. Premarin in tablet form offers the same convenience (one medication, three types of estrogen) as the cream, but taken orally.

Depending on your symptoms, the dosing regimen for oral Premarin can be recommended daily, or on a cyclic or timed treatment schedule.

In the U.S., you can purchase a 30-day supply of Premarin for $240.00, or $8 per capsule.

For lower prices, you can buy from, where a 28-day supply of Premarin costs as little as $29.00, or about $1.03 per capsule — a savings of about 87%.

Prempro Cost and Convenience

Prempro, or Premplus, (estrogen/medroxyprogesterone), much like the CombiPatch, contains two hormones (an estrogen and a progestin). These two hormones are often prescribed together. If your doctor has recommended this type of therapy and you prefer oral medications, Prempro may offer both convenience and savings in one tiny package.

Prempro is used to combat menopausal symptoms such as hot flashes and vaginal dryness. The included progestin hormone may also provide safety benefits for the uterus. Typically, women take one tablet of Prempro once a day for 28 days.

A one-month supply of Prempro in the United States costs $272.00, or $9.70 per tablet.

At, you can buy the same one-month supply of Prempro for as little as $43.00 ($1.54 per tablet — an 84% savings), depending on the specific dose of Prempro you require.

Home Replacement Internal Devices

Estring Cost and Convenience

The Estring (estradiol vaginal ring) is a small device placed in the vaginal canal for up to 90 days. It releases estradiol as long as it’s inserted, passively combating vaginal dryness with very localized, targeted treatment. This means the user doesn’t have to remember to take daily capsules or apply a topical cream.

In addition to the increased potential for spontaneity Estring allows women, the localized treatments mean less estrogen hits the user’s bloodstream. This method often produces fewer unwanted symptoms of hormonal replacement therapy.

These convenient benefits don't come cheap. In the United States, one Estring device costs about $550.00, or approximately $184.00 per month.

Alternatively, you can purchase Estring for just $108.00 at, which lowers the monthly cost to about $36 — a savings of about 80%.

Saving Money on Popular Medications for Women in Menopause

Since many menopausal women need to take hormonal medications for at least a while, doesn’t take long for costs to add up. Finding an Canadian online pharmacy that sells both brand name and generic medications for less can save you a lot of money.

At, we prioritize your safety as well as your savings. We maintain strict safety standards from the Canadian International Pharmacy Association (CIPA) and the International Pharmacy Association of British Columbia (IPABC). Furthermore, we only source medications from suppliers who follow these protocols as well.

However, you don’t have to take our word for it. Trust over 400,000+ unbiased online pharmacy customer reviews reporting consistent satisfaction. We do what we do because we care about you, your time, and your quality of life, which is why our call center is also staffed with knowledgeable, friendly representatives.

If you call or email us for answers, you’ll be speaking with a person you can trust, not an automated service or voicemail box. We can help you understand your prescription, navigate the ordering process, and even take advantage of our lowest price guarantee.

Purchasing the medication you need to manage your menopausal symptoms can be frustrating, expensive, and even scary — but we’re here to help make sure it isn’t so.

Please don’t hesitate to give a call at 1-866-539-5330, and we’ll help you find what you need. We look forward to helping you save money!

The information provided on the website is intended to facilitate awareness about healthcare products and medical conditions generally but it is not a substitute for professional medical attention or advice. You should always speak with a qualified healthcare practitioner before taking any prescription or non-prescription drug.
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